Abstract: To fulfill the promise of Precision Medicine, genomic data from the research lab must be integrated into clinical practice. In this panel, experts share their experience of successfully integrating a next-generation sequencing test (EXaCT-1) into the clinical setting. A core guiding principle of the initiative was to store discrete, variant-level genomic data in both the Electronic Health Record (EHR) and research database; this allows for customizable data views, decision support for clinical care, and analysis for research purposes. The monumental task required coordination and build between multiple departments, vendors, clinical and research information system personnel. Each panelist relays the unique challenges and pragmatic aspects of project design, information system build, system and workflow integration, data flow and storage from their perspective. We also describe our strategy around use of controlled vocabularies and existing vendor architecture for storing genomic data, so as to prevent future invalidation of data representation that may occur as these systems evolve independently.

Learning Objective 1: Understand Governance and institutional strategy for bringing Precision medicine in to clinical practice

Learning Objective 2 (Optional): Use of Next Generation Sequencing data for cancer care

Learning Objective 3 (Optional): Consider options around representation of genomic data in EHRs and using it for Clinical Decision Support (CDS)

Learning Objective 4 (Optional): Workflow implications of integrating a genomic information system in to an existing systems model


Sameer Malhotra (Presenter)
Weill Cornell Medicine

Curtis Cole (Presenter)
Weill Cornell Medicine

Olivier Elemento (Presenter)
Weill Cornell Medicine

David artz (Presenter)
Standard Molecular, Inc

Thomas Campion (Presenter)
Weill Cornell Medicine

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