Abstract: Women are at higher risk for autoimmunity while men are more likely to die of infectious disease. To better understand immune system sex differences, we performed an integrated multi-cohort analysis of gene expression microarrays, and identified a robust gene expression Immune Sex Expression Signature (ISEXS) between healthy men and women in white blood cells. We found that autosomal ISEXS gene expression changed with age, with implications for autoimmunity.
Learning Objective 1: Understanding how sex and age interact to affect the immune system
Learning Objective 2 (Optional): The importance of including sex and gender in biological studies
Erika Bongen (Presenter)
PJ Utz, Stanford University
Purvesh Khatri, Stanford University