Abstract: Although kidney transplantation is the preferred treatment for end-stage renal disease patients, rejection can complicate matters. In this work, we compare the immune repertoire of kidney rejections with those of stables by leveraging RNA-seq data. After integration with the gene expression, several genes were associated with organ rejection and clinical outcome. This work shows that new biological insights can be discovered through the integration of immune repertoire and gene expression using only one data source.
Learning Objective 1: To teach the audience about extracting immune repertoire from RNA-seq data and about the integrative analysis between it and the gene expression.
Akshay Ravoor (Presenter)
University of California, San Francisco
Silvia Pineda, University of California, San Francisco
Tara Sigdel, University of California, San Francisco
Dmitry Rychkov, University of California, San Francisco
Oriol Bestard, Bellvitge Biomedical Research Institute
Minnie Sarwal, University of California, San Francisco
Marina Sirota, University of California, San Francisco