Abstract: Appropriate innate immune responses are important for our defense against pathogenic infection and disease. Proteins such as STING that integrate chemical signals within our immune cells are critical to activating inflammation at the right times and in the right context. The contribution of human genetic diversity to STING activity is only partially understood. In this work, we used structural bioinformatics approaches to analyze polymorphic, Mendelian, and cancer variants of STING to determine their potential functions.

Learning Objective 1: Identify novel molecular information from simulations for how human genomic variants affect protein function

Learning Objective 2 (Optional): Combine molecular information with additional knowledge to interpret functional effects of genomic variation

Learning Objective 3 (Optional): Discuss how informaiton at multiple biologic levels could be combined using knowledge management systems to increase interpretive resolution


Michael Zimmermann (Presenter)
Mayo Clinic

Emily Voigt, Mayo Clinic
Iana Haralambieva, Mayo Clinic
Inna Ovsyannikova, Mayo Clinic
Schaid Daniel, Mayo Clinic
Gregory Poland, Mayo Clinic
Richard Kennedy, Mayo Clinic

Presentation Materials: